Human Recombinant Superoxide dismutase Protein Pre-Formed Fibrils

Nature

Recombinant

Tag/Conjugate

Unconjugated

Alternative Names

Superoxide dismutase1 Protein; ALS1 Protein ; SOD1 Protein; IPOA Protein

Purity

≥95%

Format

Liquid

Concentration

Batch dependent - please inquire should you have specific requirements

Buffer

PB, pH 7.4, 5 mM EDTA, 50 mM DTT

Preservative

None

Storage

Store at -80°C

Introduction

Superoxide dismutase (SOD) is an endogenous intracellular enzyme found in almost every cell in the body. In general, SODs play a crucial role in antioxidant defense mechanisms. There are two main types of SOD in mammalian cells. One form (SOD1) contains homodimers of Cu and Zn ions and is found in the cytoplasm. The second form (SOD2) is a manganese-containing enzyme located in the mitochondrial matrix. It is an 80 kDa homotetramer. The third form (SOD3 or EC-SOD) is similar to SOD1 in that it includes Cu and Zn ions, but differs in that it is a 30 kDa homotetramer present only in the extracellular space. SOD3 can also be distinguished by its heparin-binding capacity. It has been shown in vitro that Cu-Zn SOD (SOD1) fibrils can be transferred into cells and act as seeds to induce aggregation of endogenously expressed SOD1.

Entrez Gene ID

6647

Keywords

Cancer; Cell Signaling; Chaperone Proteins; Oxidative Stress; Protein Trafficking