Molecular Weight
app. 44 kDa
Alternative Names
simvastatin; Zocor; Synvinolin; Sinvacor; Denan; Lipex
Purity
chromatography, dialysis
Concentration
1 mg/mL working concentration
Reconstitution
Reconstitute with 1 ml PBS without azide.
Introduction
Simvastatin is a lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.
Antigen Description
Simvastatin, covalently linked to horseradish peroxidase
Keywords
drug-HRP conjugate, drug-conjugate, simvastatin HRP conjugate
Citations
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