Alternative Names
SARS-CoV-2 ORF3b; SARS-CoV-2; SARS-CoV-2 ORF3b protein
Buffer
50 mM Tris-HCl, pH 7.5, 270 mM Sucrose, 150 mM NaCl, 0.1 mM EGTA, 0.1 % 2-mercaptoethanol, 0.03 % Brij-35
Storage
Store at -80°C. Avoid repeated freeze-thaw cycles
Introduction
The SARS-CoV-2 (COVID-19) coronavirus genome has 89% sequence similarity with the bat SARS-like CoVZXC21 coronavirus, and 82% similarity with human SARS-CoV coronavirus. The orf1a/b, S, E, M, and N proteins also share a high degree of phylogenetic similarity with bat, civet, and human SARS coronaviruses. Notable differences in sequence are found in the SARS-CoV-2 spike protein’s receptor binding domain, which has only 40% amino acid overlap with other related viruses. Furthermore, the SARS-CoV-2 orf3b protein represents a completely novel short protein.
Keywords
SARS-CoV-2 ORF3b; SARS-CoV-2; SARS-CoV-2 ORF3b protein
Citations
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