SARS-CoV-2 Envelope Peptide

Product Overview

10 amino acids near the amino terminus of SARS E protein.

Target

SARS-CoV-2 Envelope Protein

Nature

Synthetic

Tag/Conjugate

Unconjugated

Alternative Names

SARS-CoV-2; SARS-CoV-2 Peptide; SARS-CoV-2 E Peptide; SARS-CoV-2 Envelope Peptide; SARS-CoV-2 Envelope

Format

Liquid

Concentration

200 ug/mL

Buffer

PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

Preservative

0.02% sodium azide

Storage

Store SARS-CoV-2 Envelope Peptide at -20˚C, stable for one year.

Introduction

Coronavirus envelope (E) proteins are short (100 residues) polypeptides that contain at least one transmembrane (TM) domain and a cluster of 2-3 juxtamembrane cysteines. These proteins are involved in viral morphogenesis and tropism, and their absence leads in some cases to aberrant virions, or to viral attenuation. In common to other viroporins, coronavirus envelope proteins increase membrane permeability to ions, plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.

Keywords

SARS-CoV-2; SARS-CoV-2 Peptide; SARS-CoV-2 E Peptide; SARS-CoV-2 Envelope Peptide; SARS-CoV-2 Envelope