General Notes
This product (Catalog No. CABT-L1309W) is a mouse-derived monoclonal antibody raised against ricinus communis Ricin RTA. Ricin is an extremely toxic plant protein, classified as a type II ribosome-inactivating lectin, derived from the seeds of the castor oil plant (Ricinus communis). The toxin consists of two disulfide-linked polypeptide chains: an enzymatic A chain (RTA) that catalytically depurinates a specific adenine residue in the 28S rRNA of the 60S ribosomal subunit, thereby irreversibly inhibiting protein synthesis and causing cell death, and a B chain (RTB) that facilitates binding to cell surface galactosides and subsequent endocytosis. Ricin occurs naturally in castor beans at concentrations of 1-5% by weight in the mash remaining after oil extraction, from which it can be isolated using relatively simple purification methods involving aqueous extraction and chromatography.
CABT-L1309W is suitable for use in ELISA, IHC applications.
CABT-L1309W is supplied as a lyophilized formulation in Lyophilized from 0.01M sodium phosphate, 0.15M sodium chloride, 1% dextran, 1% mannitol, pH 7.5. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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