Product Overview
Rhinovirus type 1A lysate produced from MRC-5 or HeLa cells. Purified using sucrose density gradient ultracentrifugation, heat-inactivated and tested for absence of viral growth in validate tissue culture infectivity assays.
Introduction
Human rhinoviruses (HRVs) were first discovered in the 1950s in an effort to identify the causative agent of the common cold. HRVs are positive-sense, single-stranded RNA viruses of the family Picornaviridae, genus Enteroviridae. HRVs were once classified into only two species, HRV-A and -B, according to phylogenetic sequence criteria. However, testing of clinical specimens in the 1960/70s yielded around 100 different strains, which were subsequently serotyped. This led to the division of the original 99 strains into two the species HRV-A (containing 74 serotypes) and HRV-B (containing 25 serotypes). The HRV genome is translated into a single polyprotein product that is cleaved by virally-encoded proteases to produce 11 proteins: capsid proteins VP4, VP2, VP3, VP1 and non-structural proteins 2A, 2B, 2C, 3A, 3B, 3C and 3D.
COA
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