Product Overview
Recombinant Viral wnvNS3 Protease was expressed in E. coli.
Tag/Conjugate
Unconjugated
Purity
> 95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Format
Lyophilized from a 0.2 μm filtered solution in Tris and NaCl
Storage
2-8°C short term, -20°C long term
Introduction
NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.
Antigen Description
Infection of mosquito-borne West Nile Virus can cause severe neurological disease and can be epidemic. Two non-structural proteins, NS3 and NS2b, play an essential role in viral replication and are therefore a potential target for treatment and prevention of West Nile Virus disease. NS3 consists of a trypsin-like serine protease with a catalytic triad (His51, Asp75, Ser135) and a putative helicase. Requiring NS2b as the co-factor, NS3 protease processes viral polyprotein precursor.
Keywords
WNV NS3 transactivated protein; West Nile Virus NS3; NS 3; NS3; NS3P; p70; Serine protease/NTPase/helicase; WNV NS3 Protease protein
Citations
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