Molecular Weight
39.9 kDa
Purity
> 95% as determined by HPLC
Buffer
Lyophilized from 0.22um filtered solution in PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization
Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week
Reconstitution
Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Introduction
G protein–coupled receptor, class C, group 5, member D (GPRC5D) is a bona fide target for rationally designed immunotherapeutic strategies owing to its preferential expression on plasma cells, with preclinical studies showing activity in a BCMA antigen escape model.5 GPRC5D expression on CD138 cells is independent of BCMA expression. Normal tissue expression is restricted to skin (hair follicles and eccrine glands) and the testis (seminiferous tubules), thus the potential for undesired on target/off-tumor effects is small. Currently, multiple innovative GPRC5D-targeted treatment modalities, including cell-based and antibody-based, are under active clinical development.
Keywords
GPRC5D; G protein-coupled receptor class C group 5 member D
Citations
Publication ()
Have you cited DAG-WT1228 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
