Molecular Weight
21.64 kDa
Purity
> 95% as determined by HPLC
Buffer
Lyophilized from 0.22um filtered solution in PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization
Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week
Reconstitution
Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Introduction
Transmembrane 4 L6 family member 1 is a protein that in humans is encoded by the TM4SF1 gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.
Keywords
TM4SF1; Transmembrane 4 L6 family member 1
Citations
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Bae, S; Shim, SH; et al. Combined Omics Analysis Identifies Transmembrane 4 L6 Family Member 1 as a Surface Protein Marker Specific to Human Mesenchymal Stem Cells. STEM CELLS AND DEVELOPMENT 20:197-203(2011).
Lekishvili, T; Fromm, E; et al. The tumour-associated antigen L6 (L6-Ag) is recruited to the tetraspanin-enriched microdomains: implication for tumour cell motility. JOURNAL OF CELL SCIENCE 121:685-694(2008).