Recombinant HTLV Mosaic Protein (a.a. 374-400, 190-207) [GST]

Product Overview

Recombinant HTLV protein fused with GST at N-terminus was expressed in E. coli and purified by proprietary chromatographic technique.

Nature

Recombinant

Tag/Conjugate

GST

Purity

> 95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.

Buffer

60mM NaCl, 50mM Tris-HCl pH 8.0, 0.25% Sarkosil, 50% glycerol and 10mM glutathione.

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).