Recombinant Human COMP Protein [His]

Name: Recombinant Human COMP Protein [His]
SKU: DAGP49747
Rating: 5 (1 reviews)

Recombinant Human Cartilage oligomeric matrix protein from HEK293 Cells [FLAG]

COA

SDS

Datasheet

Summary

Target

COMP

Nature

Recombinant

Tag/Conjugate

His

Molecular Weight

82 kDa including tags

Alternative Names

Cartilage oligomeric matrix protein; COMP

Format

Lyophilized

Buffer

Lyophilized from sterile PBS, pH 7.4

Preservative

None

Storage

Store at -20°C long term. Avoid freeze / thaw cycle. Please see notes section.

Reconstitution

Add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely.

Introduction

COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.

Keywords

Cartilage oligomeric matrix protein; COMP

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Parikh-friendly permutations and uniformly Parikh-friendly words

AUSTRALASIAN JOURNAL OF COMBINATORICS

Authors: Teh, Wen Chean

Abstract

The notion of Parikh-friendly permutations, originating from the study of Parikh matrices, was recently introduced by [Salomaa, Lec. Notes in Comp. Sci. 11011, Springer, Cham (2018), 100-112]. In this study, we show not only that every permutation is Parikh-friendly, but also that there exists a single word that witnesses the Parikh-friendliness of every permutation on a given ordered alphabet. In fact we introduce a relativized version of a Parikh-friendly permutation. As a result, words that are uniformly Parikh-friendly in a wider sense are effectively constructed.

Deciphering the mode of action and position of genetic variants impacting on egg number in broiler breeders

BMC GENOMICS

Authors: Tarsani, Eirini; Kranis, Andreas; Maniatis, Gerasimos; Avendano, Santiago; Hager-Theodorides, Ariadne L.; Kominakis, Antonios

Abstract

Background: Aim of the present study was first to identify genetic variants associated with egg number (EN) in female broilers, second to describe the mode of their gene action (additive and/or dominant) and third to provide a list with implicated candidate genes for the trait. A number of 2586 female broilers genotyped with the high density (similar to 600 k) SNP array and with records on EN (mean = 132.4 eggs, SD = 29.8 eggs) were used. Data were analyzed with application of additive and dominant multi-locus mixed models. Results: A number of 7 additive, 4 dominant and 6 additive plus dominant marker-trait significant associations were detected. A total number of 57 positional candidate genes were detected within 50 kb downstream and upstream flanking regions of the 17 significant markers. Functional enrichment analysis pinpointed two genes (BHLHE40andCRTC1) to be involved in the 'entrainment of circadian clock by photoperiod' biological process. Gene prioritization analysis of the positional candidate genes identified 10 top ranked genes (GDF15, BHLHE40, JUND, GDF3, COMP, ITPR1, ELF3, ELL, CRLF1andIFI30).Seven prioritized genes (GDF15, BHLHE40, JUND, GDF3, COMP, ELF3, CRTC1)have documented functional relevance to reproduction, while two more prioritized genes (ITPR1andELL) are reported to be related to egg quality in chickens. Conclusions: Present results have shown that detailed exploration of phenotype-marker associations can disclose the mode of action of genetic variants and help in identifying causative genes associated with reproductive traits in the species.