Molecular Weight
16.2 kDa
Purity
> 95% as determined by SDS-PAGE
Buffer
20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0
Introduction
CD40 is an antigen on the surface of immune cells known as T lymphocytes, B lymphocytes, and dendritic cells. It binds to a protein called CD40 ligand (CD40L), which is found on natural killer (NK) cells. Interestingly, CD40 is also found on activated T cells, and when it binds to CD40L on NK cells, it can trigger their tampering of the immune response, known as the NK's suppressive control. This CD40-CD40L interaction is crucial for NK surveillance of CD40-expressing T cells.
Keywords
CD40 ligand; CD40LG
Citations
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Sanchooli, J; Ramroodi, N; et al. Relationship between metalloproteinase 2 and 9 concentrations and soluble CD154 expression in Iranian patients with multiple sclerosis. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES 30:235-242(2014).
Ghia, P; Caligaris-Cappio, F; et al. Monoclonal B-cell lymphocytosis: right track or red herring?. BLOOD 119:4358-4362(2012).
COA
Certificate of Analysis
