Product Overview
This recombinant antigen has been prepared from the complete ORF of the eno1 gene, which codifies the glycolytic enzyme 2-phospho-D-glyceratehydro-lyase from the fungus Candida albicans
Specificity
Immunoreactive with sera of of infected individuals
Purity
> 95% as determined by SDS-PAGE
Buffer
20mM phosphate buffer, pH8, 1M NaCl, 0.1% polyoxyethylene (10) tridecyl ether
Storage
2-8°C short term, -20°C long term
Introduction
Candida albicans is the most frequently isolated fungal pathogen of humans, affecting immunocompromised patients ranging from premature infants to AIDS sufferers. Systemic infections have an attributed mortality of 30-50%. C. albicans is a diploid organism which has eight sets of homologous chromosomes. It has a genome of approximately 16 Mb (haploid), about 30% greater than S. cerevisiae (baker's yeast).
Antigen Description
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.
Keywords
C albicans; C. albicans; Thrush; Fungi; Saccharomycotina; Ascomycota; Saccharomycetales; Saccharomycetaceae; Candida albicans; Candida; Candida stellatoidea; Oidium albicans; Enolase; 2-phospho-D-glycerate hydrolase; Candida albicans enolase
Citations
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COA
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