Suitable for use to measure free Ranibizumab in patient samples.
Recommended antibody pair for pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB240 - CABT-ZB241
Recommended Working Concentration: 0.01-0.1 μg/ml
Summary
Specifications
Antibody Isotype
IgG1, κ
Clone
21E23
Immunogen
Ranibizumab
Conjugate
Unconjugated
Applications
Application Notes
Suitable for use in PK bridging ELISA. We recommend the following for sandwich ELISA (Capture - Detection): CABT-ZB240 - CABT-ZB241 Recommended Working Concentration: 0.01-0.1 μg/ml
General Notes
We recommend the following antibody pair to develop a pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB240 - CABT-ZB241 CABT-ZB241 is recommended for use as a detection antibody when paired with CABT-ZB240 as a capture antibody. Ranibizumab with trade name Lucentis, is an FDA-approved drug for the treatment of patients with neovascular (Wet) age-related macular degeneration (AMD) and macular edema following retinal vein occlusion (RVO). It is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment. Ranibizumab binds to vascular endothelial growth factor A (VEGF-A) and blocks its activity.
Target
Alternative Names
Mouse monoclonal antibody to Lucentis; Lucentis; Ranibizumab; rhuFab V2; UNII-ZL1R02VT79
Citations
Publication ()
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