Human C2 Protein

Name: Human C2 Protein
SKU: DAG4652
Rating: 5 (1 reviews)

Human C2 Protein, natural protein

COA

SDS

Datasheet

Summary

Product Overview

Human C2 Protein

Nature

Native

Tag/Conjugate

Unconjugated

Purity

> 95% by SDS-PAGE

Format

Frozen liquid

Concentration

0.5 mg/ml (see Certificate of Analysis for exact conc.)

Buffer

10 mM sodium phosphate, 145 mM NaCl, pH 6.0

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

Antigen Description

C2 is central to the activation of both the classical and the lectin pathways of complement. It forms the proteolytic subunit of the C3 and C5 convertase of both pathways. Initiation of each pathway generates proteolytic enzyme complexes which are bound t

Keywords

C2; complement component 2; CO2; ARMD14; complement C2; C3/C5 convertase; complement component C2;

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Documents

pdf COA

pdf SDS

pdf Datasheet

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Customer Reviews

References

Segmental motion at the peak of the ossification foci is independent risk factor except for mal-alignment and thick ossification foci for poor outcome after laminoplasty for cervical ossification of the posterior longitudinal ligament: analyses in patients with positive K-line, lordotic alignment, and lower canal occupying ratio

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH

Authors: Saito, Junya; Koda, Masao; Furuya, Takeo; Maki, Satoshi; Ijima, Yasushi; Kitamura, Mitsuhiro; Miyamoto, Takuya; Orita, Sumihisa; Inage, Kazuhide; Hasue, Fumio; Fujiyoshi, Takayuki; Kamiya, Koshiro; Ikeda, Yoshikazu; Nakajima, Fumitake; Hashimoto, Mitsuhiro; Noguchi, Hiroshi; Takahashi, Hiroshi; Yamazaki, Masashi; Ohtori, Seiji

Abstract

PurposeTo elucidate the independent preoperative factors that have a significant impact on poor surgical outcome after laminoplasty for K-line (+) ossification of the posterior longitudinal ligament (OPLL). Analyses in K-line (+) patient population can exclude the influence by mal-alignment and thick OPLL, both of which are well known two major factors that have significant impact on clinical outcome.MethodsThe present study included 72 patients (50 male and 22 female) who underwent laminoplasty for K-line (+) cervical OPLL and were followed-up for at least 1year. Recovery of Japanese Orthopedic Association score (JOA score) for cervical myelopathy was used as the measure of clinical outcome. For radiographic assessment, the type of OPLL, the maximum OPLL occupation ratio, the C2-C7 angle, and the segmental range of motion at the peak of OPLL (segmental ROM) were assessed. To elucidate the factors that are significantly associated with a poor clinical outcome after laminoplasty for K-line (+) OPLL, statistical analyses were conducted.ResultsThe mean preoperative JOA score was 8.9 points and improved to 12.8 points after surgery. The recovery of JOA score was 47 35%. Stepwise logistic regression following univariate analyses revealed that preoperative segmental ROM at the peak of OPLL is an independent factor associated with a poor outcome (p = 0.04, odds ratio = 1.15).Conclusions Large preoperative segmental ROM at the peak of the OPLL is an independent factor that has significant impact on poor surgical outcome after laminoplasty for K-line (+) OPLL.

Curious Case of Atypical Hangman's Fracture: C2-C3 Listhesis without Pars Fracture

JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE

Authors: Jain, Surendra; Mishra, Keshav; Gandhi, Ashok; Garg, Deepak

Abstract

Traumatic spondylolisthesis of axis or hangman's fracture is the second most common C2 vertebra injury. We present a report of a young man presenting with a history of fall from height with C2 to C3 spondylolisthesis without any evidence of injury to pars interarticularis but with associated injury to capsular ligament of facet joint along with posterior spinous ligamentous injury. The patient underwent intraoperative reduction in listhesis with posterior screw fixation. The patient showed uneventful postoperative course with neurological improvement at 6-week follow-up. Hangman's fracture refers to a diverse group of injury in which the soft tissue injury has an equally important part to play as the bone fracture.