Specifications
Immunogen
GPT (AAH18207, 1 a.a. ~ 497 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Target
Alternative Names
glutamic-pyruvate transaminase (alanine aminotransferase); Glutamic--pyruvic transaminase 1; ALT1; EC 2.6.1.2; AAT1; alanine aminotransferase 1; Glutamate pyruvate transaminase 1; glutamic-alanine transaminase 1; Glutamic--alanine transaminase 1; GPT1; GP
Product Background
Antigen Description
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.
Mouse monoclonal antibody raised against a full length recombinant GPT.
Pathway
Alanine and aspartate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Amino acid synthesis and interconversion (transamination), organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem
Citations
Publication ()
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COA
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