Anti-Lifr polyclonal antibody

Antibody Isotype

IgG

Immunogen

Recombinant mouse LIFR protein

Conjugate

Alternative Names

LIFR; leukemia inhibitory factor receptor; LIF-R; LIF receptor; D-factor/LIF receptor; leukemia inhibitory factor receptor alpha chain; soluble differentiation-stimulating factor receptor; LIF; AW061234; A230075M04Rik;

Entrez Gene ID

Antigen Description

Mouse Leukemia inhibitory factor receptor, also known as LIF receptor, CD118 and LIFR, is single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 2 subfamily. LIFR contains six fibronectin type-III domains. LIFR is a signal-transducing molecule. It may have a common pathway with IL6ST. LIFR is the receptor for leukemia inhibitory factor (LIF), a pleiotropic cytokine affecting the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. The soluble form of LIFR inhibits the biological activity of LIF by blocking its binding to receptors on target cells. LIF action appears to be mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an μ subunit that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex.

Pathway

Adipogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; ESC Pluripotency Pathways, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; PluriNetWork, organism-specific biosystem;