IA, ELISA This antibody stabilizes receptor conformations and inhibits receptor function, with a reported affinity of 77 pM. It is suitable for receptor structural biology and functional inhibition studies. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded
General Notes
Llama anti-mouse 5-HT3A receptor monoclonal VHH, clone VHH15 binds near the extracellular neurotransmitter-binding region. One VHH binds per receptor subunit and stabilizes a nonconducting/inhibited state. Source-reported affinity is 77 pM, and later work reported inhibition of serotonin-evoked activity with an IC50 of 29 nM. Later sources contain a VHH15/VHH15S naming and sequence nuance; complete sequence reconciliation and broader Cys-loop-receptor cross-reactivity were not available. The supplied source identifies the antibody format as VHH / nanobody; no additional product-specific preparation, formulation, size, storage or shipping information was provided.
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