Directly binds LAP1 and qualitatively competes with TorsinA binding in vitro. No defensible Kd/Ki/IC50 was found. LAP1 R563 is the target protein's functional arginine finger; ATPase activation data belong to the LAP1/Torsin mechanism, not to VHH-BS1 potency. Broad specificity and validated intracellular applications were not reported.
IA, ELISA This antibody binds directly to LAP1 and competitively inhibits TorsinA binding in vitro. It serves as a crystallization chaperone and is applicable to LAP1/Torsin structural biology and protein–protein interaction studies. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded
General Notes
Alpaca anti-human LAP1 monoclonal VHH / nanobody, clone VHH-BS1 is represented by PDB 4TVS and is associated with Human LAP1 luminal domain. Reported applications include LAP1/Torsin structural biology, crystallization chaperone, protein–protein competition studies. Binds immediately around LAP1 R563 and overlaps the proposed TorsinA-interaction region. It was used primarily to facilitate LAP1 crystallography. Directly binds LAP1 and qualitatively competes with TorsinA binding in vitro. No defensible Kd/Ki/IC50 was found. LAP1 R563 is the target protein's functional arginine finger; ATPase activation data belong to the LAP1/Torsin mechanism, not to VHH-BS1 potency. Broad specificity and validated intracellular applications were not reported. The supplied source identifies the structural format as VHH / nanobody. No additional product-specific preparation, formulation, size, storage, or shipping information was provided in the supplied material.
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