Protein expressed in 293T cell transfected with human LDHA expression vector
Conjugate
Unconjugated
Applications
Application Notes
ELISA: 1:250-1:1000 We recommend the following for sandwich ELISA (Capture - Detection): CABT-ZC1204 - CABT-ZC1203
Product Background
Antigen Description
Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 84?C89% sequence similarities and 69?C75% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure. The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1a (HIF1a). LDHB is also known to be upregulated in many cancers.
Citations
Publication ()
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