Anti-ENPP7 monoclonal antibody, clone MAFB4421

Antibody Isotype

IgG1

Clone

MAFB4421

Immunogen

Recombinant human ENPP7 protein

Conjugate

Alternative Names

ENPP7; ectonucleotide pyrophosphatase/phosphodiesterase 7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7; alk SMase; NPP-7; E-NPP 7; alkaline sphingomyelinase; intestinal alkaline sphingomyelinase; alkaline sphingomyelin phosphodiestera

Entrez Gene ID

UniProt ID

Q6UWV6

Antigen Description

Ectonucleotide pyrophosphatase/ phosphodiesterase 7 (ENPP7), also known as alkaline sphingomyelinase (alk-Smase), is a member of nucleotide phosphodiesterase (NPP) family and is expressed in the intestines and human bile. ENPP7 is a single-pass type Ⅰmembrane protein, and is localized at the surface of the microvillar membrane in small intestine enterocytes, as well as in endosome-like structures and in Golgi complex. The main function of ENPP7 is to convert the dietary sphingomyelin into ceramide, the sphingolipid messengers via hydrolyzation. ENPP7 is reported to exert a phospholipase C activity toward palmitoyl lyso-phosphocholine. The activity of this enzyme is inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Further, It has been shown in studies that decreased levels of ENPP7 may be associated with human colon cancer.

Pathway

Glycosphingolipid metabolism, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Sphingolipid metabolism, organism-specific biosystem; Sphingolipid metabolism, organism-specific biosystem; Sphingolipid metabolism, conserved biosystem;