ELISA; Matched pair Antibody available for PNU-159682[BSA], PNU-159682 Antibody(Cat.# CABT-L3111)
Format
Liquid
Concentration
Batch dependent - please inquire should you have specific requirements.
Buffer
0.01M PBS, pH 7.2
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Antigen Description
PNU-159682 inhibits a panel of human tumor cell lines with IC70 values in the range of 0.07-0.58 nM, and is 2,360- to 790-fold and 6,420- to 2,100-fold more potent than MMDX and doxorubicin, respectively. PNU-159682 (100 μM) weakly inhibits topoisomerase II unknotting activity. PNU-159682 (10 μM)-DNA adducts contain one or two drug molecules bound to double-stranded DNA. PNU-159682 shows cytotoxic effect on CAIX-expressing SKRC-52 cells with IC50 of 25 nM.
Keywords
PNU159682; SCHEMBL3801318
Citations
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