Piperacillin sodium is a broad-spectrum ureidopenicillin antibiotic effective against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. It inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins and is often used in combination with tazobactam to overcome β-lactamase-mediated resistance. Clinically, it is employed for severe infections such as sepsis, pneumonia, and intra-abdominal infections. Its rapid renal elimination necessitates dose adjustment in renal impairment.
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