Chiral tetraoxacalix[2]arene[2]triazine-based organocatalysts for Enantioselective Aldol reactions
TETRAHEDRON LETTERS
Authors: Genc, Hayriye Nevin; Ozgun, Ummu; Sirit, Abdulkadir
Abstract
Novel efficient chiral tetraoxacalix[2]arene[2]triazine-based organocatalysts have been designed and synthesized from the reaction of tetraoxacalix[2]arene[2]triazine with R/S-phenylethylamine or R/S-1-naphthylethylamine for the Aldol reaction of acetone with aromatic aldehydes to furnish the Aldol adducts in 71-92% yields with excellent enantioselectivities (78-99%). (C) 2019 Elsevier Ltd. All rights reserved.
Synthesis and Biological Activity of 1,11-bis(6,7-Methylenedioxy- and 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinolin-1-YL)Undecanes
CHEMISTRY OF NATURAL COMPOUNDS
Authors: Terent'eva, E. O.; Saidov, A. Sh.; Khashimova, Z. S.; Tseomashko, N. E.; Sasmakov, S. A.; Abdurakhmanov, D. M.; Vinogradova, V. I.; Azimova, Sh. S.
Abstract
Two bis(tetrahydroisoquinoline) derivatives of undecane were synthesized from brassylic acid and 3,4-dimethoxy-(or methylenedioxy-)phenylethylamine. It was shown that 4a and 4b were highly cytotoxic for cancer-cell cultures and less toxic to healthy cells and exhibited noticeable antimicrobial activity against Gram-positive and Gram-negative bacteria and fungal strain Candida albicans. The antifungal activity of 4a exceeded that of the reference drug nystatin.