Multiple SARS-CoV-2 variants are circulating globally. Several new variants emerged in the fall of 2020, most notably:
Creative Diagnostics has produced a collection of recombinant antigens for these variants. The reagents can be used to evaluate the efficacy of the antibodies and vaccination.
Cat. No. | Product Name | Source | Additional Information |
DAGC488 | Recombinant SARS-CoV-2 Spike S1 (HV69-70/Y144 deletion, N501Y, A570D, D614G, P681H) Protein [His] | HEK293 cells | variant 20I/501Y.V1, VOC 202012/01, or B.1.1.7 |
DAGC489 | Recombinant SARS-CoV-2 Spike S1(K417N, E484K, N501Y, D614G) Protein [His] | HEK293 cells | variant 20H/501Y.V2 or B.1.351 |
Our team has been working diligently to stay abreast these new developments and are currently developing a serial of Lentiviral SARS-CoV-2 Mutation Pseudovirus.
Cat. No. | Product Name | Reporter Gene |
COVL-B117 | Pseudotyped Luciferase rSARS-CoV-2 Spike (Variant B.1.1.7) | Luciferase |
COVG-B117 | Pseudotyped GFP rSARS-CoV-2 Spike (Variant B.1.1.7) | GFP |
COVL-N439K | Pseudotyped Luciferase rSARS-CoV-2 Spike (N439K) | Luciferase |
COVG-N439K | Pseudotyped GFP rSARS-CoV-2 Spike (N439K) | GFP |
COVL-501YV2 | Pseudotyped Luciferase rSARS-CoV-2 Spike (Variant 501Y.V2) | Luciferase |
COVG-501YV2 | Pseudotyped GFP rSARS-CoV-2 Spike (Variant 501Y.V2) | GFP |
CD anti-nucleoprotein antibodies expected to detect both UK and South African variants of SARS-CoV-2. The UK variant of SARS-CoV-2 (known as VOC 202012/01, lineage B.1.1.7, or 20B/501Y.V1) has two mutations in the nucleoprotein: D3L and S235F. We have validated that our key anti-NP clones NB1, NB2, and NJ1 are able to detect the UK variant. The South African variant of SARS-CoV-2 (known as 501.V2, 20C/501Y.V2 or B.1.351 lineage) does not have any mutations in its nucleoprotein and should be detected by all our anti-COVID-19 NP MAbs.
Cat. No. | Product Name | Source | Application |
CABT-MMB1 | Mouse Anti-SARS-CoV-2 NP monoclonal antibody, clone NB1 | Mouse | Capture |
CABT-MMB2 | Mouse Anti-SARS-CoV-2 NP monoclonal antibody, clone NB2 | Mouse | Detection |
CABT-RMJ1 | Rabbit anti-SARS-CoV-2 NP monoclonal antibody, clone NJ1 | Rabbit | Detection |
Best pairs in lateral flow:If you are developing a lateral flow -based test, we recommend you start with these two capture-detection pairs: CABT-MMB1-CABT-MMB2, CABT-MMB1-CABT-RMJ1.
We are pleased to let you know that we now have the first anti-nucleoprotein antibody (CABT-MMT2) which can not react with B.1.1.7 variant strain but react with other COVD-19 viral strains.
This antibody can be used for COVID-19 antigen lateral flow testing in differentiating Variant B.1.1.7 and other viral strains.