Multiple SARS-CoV-2 variants are circulating globally. Several new variants emerged in the fall of 2020, most notably:
Creative Diagnostics has produced a collection of recombinant antigens for these variants. The reagents can be used to evaluate the efficacy of the antibodies and vaccination.
|Cat. No.||Product Name||Source||Additional Information|
|DAGC488||Recombinant SARS-CoV-2 Spike S1 (HV69-70/Y144 deletion, N501Y, A570D, D614G, P681H) Protein [His]||HEK293 cells||variant 20I/501Y.V1, VOC 202012/01, or B.1.1.7|
|DAGC489||Recombinant SARS-CoV-2 Spike S1(K417N, E484K, N501Y, D614G) Protein [His]||HEK293 cells||variant 20H/501Y.V2 or B.1.351|
Our team has been working diligently to stay abreast these new developments and are currently developing a serial of Lentiviral SARS-CoV-2 Mutation Pseudovirus.
|Cat. No.||Product Name||Reporter Gene|
|COVL-B117||Pseudotyped Luciferase rSARS-CoV-2 Spike (Variant B.1.1.7)||Luciferase|
|COVG-B117||Pseudotyped GFP rSARS-CoV-2 Spike (Variant B.1.1.7)||GFP|
|COVL-N439K||Pseudotyped Luciferase rSARS-CoV-2 Spike (N439K)||Luciferase|
|COVG-N439K||Pseudotyped GFP rSARS-CoV-2 Spike (N439K)||GFP|
|COVL-501YV2||Pseudotyped Luciferase rSARS-CoV-2 Spike (Variant 501Y.V2)||Luciferase|
|COVG-501YV2||Pseudotyped GFP rSARS-CoV-2 Spike (Variant 501Y.V2)||GFP|
CD anti-nucleoprotein antibodies expected to detect both UK and South African variants of SARS-CoV-2. The UK variant of SARS-CoV-2 (known as VOC 202012/01, lineage B.1.1.7, or 20B/501Y.V1) has two mutations in the nucleoprotein: D3L and S235F. We have validated that our key anti-NP clones NB1, NB2, and NJ1 are able to detect the UK variant. The South African variant of SARS-CoV-2 (known as 501.V2, 20C/501Y.V2 or B.1.351 lineage) does not have any mutations in its nucleoprotein and should be detected by all our anti-COVID-19 NP MAbs.
|Cat. No.||Product Name||Source||Application|
|CABT-MMB1||Mouse Anti-SARS-CoV-2 NP monoclonal antibody, clone NB1||Mouse||Capture|
|CABT-MMB2||Mouse Anti-SARS-CoV-2 NP monoclonal antibody, clone NB2||Mouse||Detection|
|CABT-RMJ1||Rabbit anti-SARS-CoV-2 NP monoclonal antibody, clone NJ1||Rabbit||Detection|
Best pairs in lateral flow：If you are developing a lateral flow -based test, we recommend you start with these two capture-detection pairs: CABT-MMB1-CABT-MMB2, CABT-MMB1-CABT-RMJ1.
We are pleased to let you know that we now have the first anti-nucleoprotein antibody (CABT-MMT2) which can not react with B.1.1.7 variant strain but react with other COVD-19 viral strains.
This antibody can be used for COVID-19 antigen lateral flow testing in differentiating Variant B.1.1.7 and other viral strains.