Product Overview
Batroxobin, isolated from Bothrops atrox snake venom, has an Mw of approximately 43kDa.
Tag/Conjugate
Unconjugated
Alternative Names
Batroxobin; Bothrops atrox; B. atrox
Buffer
Lyophilized from a concentrated (1mg/ml) solution with no additives.
Storage
Batroxobin although stable at room temperature for 3 weeks, should be stored below -18°C. reconstitution Batroxobin should be stored at 4°C between 2-7 days and for future use below -18°C. Upon For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Reconstitution
It is recommended to reconstitute the lyophilized Batroxobin in sterile 18M-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Introduction
Batroxobin is a serine protease derived from the venom of Bothrops atrox. Its molecular weight is approximately 43,000 g/mol. This thrombin-like proteolytic enzyme splits the 16 Arg-17 Gly bond in the A(alpha)-chain of fibrinogen, releasing fibrinopeptide A and leading to the clot formation through aggregation of formed of fibrin I monomer or Des-AA-monomer. In contrast to other anti-coagulants, it does not affect the functions of platelets. Hence, Batroxobin is used to determine fibrinogen in plasma, to measure a 'batroxobin clotting time' as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemia, and to test the contractile system of platelets.
Antigen Description
Batroxobin is a serin protease that reduces fibronogen levels and is originally extracted from snake venom of Bothrops Atrox. Batroxobin is used in defibrinogenation and thrombolysis and also has an effect on c-fos gene and growth factor.Batroxobin can efficiently restrain proliferation of VSMCs, by blocking the release and uptake of Ca2+, thus influencing [Ca2+].Batroxobin converts fibrinogen to fibrin through the restricted release of fibrinopeptide-A from fibrinogen to promote blood to clot. Unlike thrombin, it is not affected by heparin and hirudin.
Keywords
Batroxobin; Bothrops atrox; B. atrox
Citations
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