Contents of Kit
1. Polystyrene microwell ELISA plates coated with a purified antigen(12-1 x 8 wells), with holder in foil package containing desiccants
2. Negative Control, 1 vial of buffer 1.2 mL
3. Positive Control, 1 vial of buffer 1.2 mL
4. Calibrator A, 1 vial of buffer containing preservative, prediluted, 1.2 mL
5. Calibrator B, 1 vial of buffer containing preservative, prediluted, 1.2 mL
6. Calibrator C, 1 vial of buffer containing preservative, prediluted, 1.2 mL
7. Calibrator D, 1 vial of buffer containing preservative, prediluted, 1.2 mL
8. Sample Diluent, 1 vial – colored straw containing PBS-buffered saline, protein stabilizers and preservative, 50 mL.
9. Antibody Enzyme Conjugate, colored blue containing buffer, protein stabilizers and preservative, 12 mL
10. Wash Buffer (20 ×), 50 mL
11. TMB Chromogen, containing stabilizers, 10 mL
12. Stop Solution, Colorless, 10 mL
General Description
Islet Cell Autoantibody (ICA) is a type of autoantibody that targets antigens within the pancreatic islets, particularly the beta cells that produce insulin. These antibodies are markers of autoimmune-mediated beta-cell damage and are crucial in the diagnosis and understanding of Type 1 diabetes (T1D).
ICA antibodies are present in the majority of patients with T1D, especially around the time of diagnosis. They are detected in up to 90% of patients with newly diagnosed T1D.
The presence of multiple autoantibodies (e.g., ICA, GAD65, IA-2A) in individuals at risk for T1D can help in stratifying the risk of disease progression. Those with multiple autoantibodies have a higher risk of developing T1D within 5 years
ICA antibodies, along with GAD65 and IA-2A, can also be used to diagnose LADA, a form of diabetes that requires insulin therapy and is often misdiagnosed as Type 2 diabetes.
COA
Publication 
Loading ......
