Contents of Kit
1. Polystyrene microwell ELISA plates coated with a purified antigen(12-1 x 8 wells), with holder in foil package containing desiccants
2. Negative Control, 1 vial of buffer 1.2 mL
3. Positive Control, 1 vial of buffer 1.2 mL
4. Calibrator A, 1 vial of buffer containing preservative, prediluted, 1.2 mL
5. Calibrator B, 1 vial of buffer containing preservative, prediluted, 1.2 mL
6. Calibrator C, 1 vial of buffer containing preservative, prediluted, 1.2 mL
7. Calibrator D, 1 vial of buffer containing preservative, prediluted, 1.2 mL
8. Sample Diluent, 1 vial – colored straw containing PBS-buffered saline, protein stabilizers and preservative, 50 mL.
9. Antibody Enzyme Conjugate, colored blue containing buffer, protein stabilizers and preservative, 12 mL
10. Wash Buffer (20 ×), 50 mL
11. TMB Chromogen, containing stabilizers, 10 mL
12. Stop Solution, Colorless, 10 mL
General Description
Low-density lipoprotein receptor-related protein 4 (LRP4) is a critical component in the formation and maintenance of the neuromuscular junction (NMJ). Autoantibodies against LRP4 (Anti-LRP4 antibodies) have been identified in patients with myasthenia gravis (MG), an autoimmune disorder affecting the NMJ.
Anti-LRP4 antibodies disrupt the interaction between LRP4 and agrin, a protein essential for NMJ formation. This disruption leads to reduced activation of muscle-specific kinase (MuSK) and decreased clustering of acetylcholine receptors (AChRs), impairing neuromuscular transmission.
Anti-LRP4 antibodies serve as a diagnostic biomarker for MG, particularly in patients who are double-negative for anti-AChR and anti-MuSK antibodies. Detection of these antibodies can aid in the diagnosis of MG in such cases.
COA
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