Rabbit Anti-Human MMD Polyclonal Antibody

Objective To assess the efficacy of erenumab across the spectrum of response thresholds (>= 50%, >= 75%, 100%) based on monthly migraine days (MMD) reduction in patients with chronic migraine from a 12-week, randomized study (NCT02066415). Methods Patients (n = 667) received (3:2:2) placebo or erenumab 70/140 mg once-monthly. The proportion of patients achieving a given response threshold was assessed. A post-hoc analysis was conducted to contextualize the actual treatment benefit in subgroups of patients achieving (or not) specified response thresholds. Outcome measures included MMD, acute migraine-specific medication treatment days (MSMD) and disability. Results The proportion of patients responding to erenumab exceeded that of placebo at the >= 50% and >= 75% response thresholds. At month 3, 39.9% and 41.2% of patients on erenumab 70 and 140 mg, respectively, achieved >= 50% response versus placebo (23.5%). Similarly, at month 3, 17.0% and 20.9% of patients on erenumab 70 and 140 mg, respectively, achieved >= 75% response versus placebo (7.8%). Compared with the overall erenumab-treated population (change in MMD: -6.6 [both 70 and 140 mg]), >= 50% responders showed MMD reductions of -12.2/-12.5 for 70 mg/140 mg versus -2.6/-2.2 for those not achieving >= 50% response. >= 75% responders showed MMD reductions of -13.9/-14.8 for 70 mg/140 mg versus -5.0/-4.3 for those not achieving >= 75% response. Relative improvements in MSMD and disability were observed in responders versus overall erenumab-treated population. Conclusion For erenumab-treated patients achieving >= 50% response, the actual reduction in MMD was almost twice that of the overall population. These findings provide context for setting realistic expectations regarding actual treatment benefit experienced by patients responding to treatment.

Malaysia has been ranked as one of the top three countries in the world with deadliest roads. The aim of this study is to determine the relationship between environmental factors and the occurrence of accident cases. The road accident data were obtained from Ibu Pejabat Kontinjen (IPK) Alor Setar and the weather data were obtained from the Malaysian Meteorological Department (MMD) from the year 2013 to 2015. These data were processed through ArcGIS software 10.5. Subsequently, to determine the relationship between accident cases and environmental factors, the regression method was carried out. The result show rainfall has effects toward road accidents at the low level of rainfall. Besides that, there are two levels of temperature that lead to accidents occurring in Kedah such as cool day and warm day. The number of accident cases increased when the temperature value in cool day category increased and the number of road accident cases occurred decreased when the temperature value increased in warm day category. Meanwhile, the number of accident cases increased when the wind speed is maximum or above 20 m/s. In conclusion, the advancements in Geographical Information System (GIS) can be put to effective use in road accidents for further analysis such as spatial-temporal analysis, hotspots area analysis, shortest path analysis and emergency response analysis.