MMAE [BSA] (DAG603S)

MMAE conjugated with BSA, synthetic antigen

Target
MMAE
Nature
Synthetic
Tag/Conjugate
BSA
Molecular Weight
71KDa
Bio-activity
Drug to BSA ratio: ~4
Alternative Names
Monomethylauristatin E; Monomethyl auristatin E; MMAE
Purity
≥ 99 % of conjugates by HPLC
Format
lyophilized
Size
1mg, 5x1mg
Storage
The shelf life of this compound has not been tested, but the compound is fairly stable at RT. The compound should be stored at -20°C. After reconsitution, use immediately.
Reconstitution
Dissolve in 344.8 μL of deionized water to achieve 2.9 mg/mL in 1xPBS buffer containing sugar-based stabilizer (no preservative).
Introduction
This BSA-MMAE conjugate is designed with similar linker chemistry as ADC and is synthesized at Creative Diagnostics for our customers' usage in immunization or immunoassay. First, thiol functional groups are introduced to the BSA followed by reaction of the maleimide group of Mc-VC-PAB-MMAE to form the conjugate. The final conjugate is lyophilized from phosphate buffered saline containing sugar-based stabilizer for easy shipping and storage.
Antigen Description
MMAE (monomethyl auristatin E) is an antimitotic agent that binds to tubulin and inhibits the assembly of microtubules. Mc-VC-PAB-MMAE is a thiol reactive derivative of MMAE that containing a cathepsin cleavable valine-citruline p-aminobenzylcarbamate linkage. Mc-VC-PAB-MMAE is used to prepare antibody-drug conjugates, such as brentuximab vedotin (Seattle Genetics).
Keywords
Monomethylauristatin E; Monomethyl auristatin E; MMAE

Citations


Have you cited DAG603S in a publication? Let us know and earn a reward for your research.

Related Products


Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

Online Inquiry

Name:
Phone: *
E-mail Address: *
Technology Interest:
Type of Organization:
Service & Products Interested: *
Project Description:

Related Products

Related Resources

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

Inquiry Basket