Q: I was interested in any further details concerning DMAB-CDB25703, particularly regarding cross-reactivity with other allergens or any known background reactivity.
A: Clone 2F10 recognizes a highly defined conformational epitope on Der p 2. This epitope constitutes an important part of the IgE antibody repertoire against Der p 2.Epitope: The binding site spans residues 58–64 and 97–103. Leu61 and Lys100 facilitate essential hydrophobic interactions, ensuring high-affinity complex formation.
Reactivity: Clone 2F10 demonstrates robust binding across the Pyroglyphidae family, showing consistent potency against: Der p 2 (natural and recombinant isoforms.0101,.0103), Der f 2 (Dermatophagoides farinae), and Eur m 2 (Euroglyphus maynei). Demonstrates stringent specificity within the Pyroglyphidae family. It does not cross-react with house dust mites and storage mites allergens from the Glycyphagoidea superfamily (e.g., Gly d 2 and Lep d 2). This selectivity is governed by the low amino acid sequence identity (<40%) at the specific 2F10 epitope site, allowing for precise environmental and diagnostic profiling.
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