Inquiry Basket
Loading ......
Liposarcoma is the most common soft tissue sarcoma in adults, and can also be seen in adolescents and children. Liposarcoma usually has a large volume and is a deep, painless, gradually growing mass that most commonly occurs in the lower limbs (such as the popliteal fossa and inner thigh), retroperitoneum, perirenal area, mesenteric region, and shoulder. The incidence rate in different locations mainly depends on the subtype of the tumor, including atypical liposarcoma/well differentiated liposarcoma, dedifferentiated liposarcoma, myxoid liposarcoma, pleomorphic liposarcoma, and mixed liposarcoma.
Figure 1. Liposarcoma.
Liposarcoma usually has a large volume and is a deep, painless, gradually growing mass that most commonly occurs in the lower limbs (such as the popliteal fossa and inner thigh), retroperitoneum, perirenal area, mesenteric region, and shoulder.
The cause is currently unknown and may be related to genetics. There is a substance called "tumor causing factor" in the patient's cells. Under normal circumstances, this "tumor causing factor" is in an inactive state. However, under various stimuli, the "tumor causing factor" is activated and acts on normal adipocytes, causing abnormal growth and ultimately forming a lipoma. Genetic factors, chronic inflammation, and abnormal systemic lipid metabolism may induce lipomas.
Liposarcoma is usually a large tumor (>10cm), but can be almost any size. They mainly occur in adults, with only 0.7% of cases occurring in people under the age of 16. In adults, liposarcoma mainly occurs in middle age and later. Very rare cases occurring in children and adolescents are mainly diagnosed as mucinous liposarcoma. These five forms of liposarcoma must not only be distinguished from each other, but also from certain other soft tissue tumors. These other tumors and some of their unique histopathological features are:
1) Developmental dysplasia lipoma (benign body fluids with tissue necrosis sites and tumorous, variable size adipocytes containing variable size/shape nuclei; these tumor cells are different from most tumor cells in liposarcoma and do not overexpress the MDM2 gene);
2) Atypical spindle cell lipoma (benign tumor with mild atypical spindle cells in fibrous to mucinous matrix, mixed with vacuolated adipocytes and variable sized adipocytes, atypical nucleus);
3) Polymorphic lipoma;
4) Solitary fibroids (i.e. tumors, up to 22% of which exhibit malignant behavior) are composed of spindle shaped or oval shaped cells within a collagen background matrix, mixed with characteristic antler shaped blood vessels
Diagnosis can be made based on clinical manifestations, gross examination, and histopathology. We will describe different types of liposarcoma separately below.
| Diagnosis | Details |
| Atypical lipomatous tumor/well differentiated liposarcoma | Often a large, well-defined lobulated mass. Under the microscope, ALT/WD liposarcoma is composed of relatively mature and proliferating adipose tissue, and there is a significant difference in cell size compared to benign liposarcoma. Focal atypia and deep nuclear staining in the nuclei of adipose tissue cells are helpful for diagnosis. Commonly scattered and deeply stained interstitial cells and multinucleated interstitial cells. There are varying numbers of monovesicular or multivesicular adipocytes visible. This includes sclerosing liposarcoma, inflammatory liposarcoma, spindle cell subtypes, and may also exhibit heterologous differentiation. |
| Mucinous liposarcoma | The typical manifestation of MLS is large, painless masses with clear boundaries and multiple nodules in the deep soft tissues of the limbs. Low grade malignant cases have brown and gelatinous cross-sections. The highly malignant circular cell area appears white and fleshy. There is often no visible necrosis. At low magnification, MLS exhibits a lobulated structure with abundant cells around the lobules. Consistently circular and elliptical primitive non fat mesenchymal cells coexist with small signet ring like adipocytes. Common interstitial bleeding. MLS often shows the gradual migration of mucous areas and cell rich/circular cell areas. |
| Polymorphous liposarcoma | The swelling material is hard and often nodular, with a white to yellow section. Most tumors are composed of polymorphic spindle shaped tumor cells and bundles of spindle shaped, smaller circular cells, mixed with multinucleated giant cells and polymorphic multivesicular adipocytes. |
| Degifferentiated liposarcoma | Generally, it is a large multi nodular yellow mass containing scattered, solid, and often grayish brown non fat areas. There is often necrosis in the dedifferentiated area. Its histological features include the migration of ALT/WD liposarcoma to non fat sarcoma (mostly highly malignant). 5% to 10% dedifferentiated liposarcoma may have heterologous differentiation, but it is not related to clinical prognosis. The most common types are muscular or bone/chondrosarcoma differentiation. |
The most important prognostic factor is the location of the tumor. If the site of tumor growth can be completely surgically removed, there will be no recurrence after the tumor edge is completely removed. Tumors that occur in deep tissues have a tendency to recur multiple times, often leading to death due to uncontrolled invasive growth, dedifferentiation, and metastasis of the tumor in the local area.
| Cat. No. | Product Name | Host | Isotype | Application | |
| DCABH-1673 | Anti-FUS monoclonal antibody, clone FQS6923 | Rabbit | IgG | WB, IHC-P, FC, ICC/IF | Inquiry |
| DCABH-2792 | Rabbit Anti-FUS monoclonal antibody, clone KK10-42 | Rabbit | IgG | WB, ICC/IF, IHC, FC | Inquiry |
| Cat. No. | Product Name | Size | Target | Species | |
| CDBP1489 | Human HMGA2 blocking peptide | 100 g | HMGI-C / HMGA2 | Human | Inquiry |
| DAG-P1960 | Human FUS peptide | / | / | / | Inquiry |
Loading ......
