ELISA, IF, Crystallization Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
General Notes
TRAAK is a membrane tension-activated K+ channel that has been associated through behavioral studies to mechanical nociception. This monoclonal antibody raised against mouse TRAAK specifically binds to an extracellular epitope of the TRAAK channel.
Target
Alternative Names
KCNK4; potassium channel, subfamily K, member 4; potassium channel subfamily K member 4; K2p4.1; TRAAK; K2p4.1; MGC144821; K2P4.1 potassium channel; KCNK 4; Potassium channel subfamily K member 4; Potassium inwardly rectifying channel subfamily K member 4
Citations
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References
The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier.
TRAAK is a membrane tension-activated K + channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal antibodies in mice to show that TRAAK is localized exclusively to nodes of Ranvier, the action potential propagating elements of myelinated nerve fibers. Approximately 80 percent of myelinated nerve fibers throughout the central and peripheral nervous system contain TRAAK in what is likely an all-nodes or no-nodes per axon fashion. TRAAK is not observed at the axon initial segment where action potentials are first generated. We used polyclonal antibodies, the TRAAK inhibitor RU2 and node clamp amplifiers to demonstrate the presence and functional properties of TRAAK in rat nerve fibers. TRAAK contributes to the 'leak' K + current in mammalian nerve fiber conduction by hyperpolarizing the resting membrane potential, thereby increasing Na + channel availability for action potential propagation. We speculate on why nodes of Ranvier contain a mechanosensitive K + channel.
COA
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