Molecular Weight
app. 44 kDa
Alternative Names
indomethacin; indometacin; Indocin; Indometacine; Indomethacine
Purity
chromatography, dialysis
Concentration
1 mg/mL working concentration
Reconstitution
Reconstitute with 1 ml PBS without azide.
Introduction
Indomethacin is a synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)
Antigen Description
Indometacin, covalently linked to horseradish peroxidase
Keywords
drug-HRP conjugate, drug-conjugate, Indometacin HRP conjugate
Citations
Publication ()
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COA
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