The Role of IL-9/Il9r in Irritable Bowel Syndrome
GASTROENTEROLOGY
Authors: Beltran, Caroll; Fanning, Aine; Moloney, Gerard; Grenham, Sue; Heuston, Sinead; Melgar, Silvia; Nally, Kenneth; Cryan, John F.; Dinan, Timothy G.; Quigley, Eamonn M.
Abstract
Decreased placental IL9 and IL9R in preeclampsia impair trophoblast cell proliferation, invasion, and angiogenesis
HYPERTENSION IN PREGNANCY
Authors: Sun, Yi; Liu, Siyu; Hu, Rong; Zhou, Qiongjie; Li, Xiaotian
Abstract
Objective: Our study aimed to investigate IL9 and IL9R expression in preeclampsia and assess their effects on trophoblast biological behaviors. Methods: IL9 and IL9R expression of placenta tissue were evaluated by immunochemistry and q-PCR. Using transwell, CCK-8, and tubule formation assays measured invasion, proliferation and angiogenesis of trophoblast with adding IL9 or anti-IL9R antibody. Results: IL9 and IL9R levels were significantly decreased in preeclampsia. IL9 improved trophoblast activities. Blocking IL9/IL9R resulted in decreased proliferation, invasion, and tube-formation capability of trophoblast. Conclusions: IL9 and IL9R contribute to the pathogenesis of preeclampsia. IL9/IL9R signaling provides a new potential therapeutic target for preventing preeclampsia.
COA
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