Product Overview
C-terminal 6xHis tagged M1 (A/Thailand/1(KAN-1)/2004(H5N1)) protein (a.a. 1-252)
Format
Each vial contains 100 μg of lyophilized protein in PBS with 8M Urea.
Storage
2-8°C short term, -20°C long term
Introduction
Influenza A virus causes influenza in birds and some mammals and is the only species of influenzavirus A. Influenzavirus A is a genus of the Orthomyxoviridae family of viruses. Strains of all subtypes of influenza A virus have been isolated from wild birds, although disease is uncommon. Some isolates of influenza A virus cause severe disease both in domestic poultry and, rarely, in humans. Occasionally, viruses are transmitted from wild aquatic birds to domestic poultry, and this may cause an outbreak or give rise to human influenza pandemics.
Antigen Description
Matrix protein 1 is a peripheral membrane, cytoplasmic side and host nucleus protein which belongs to the influenza viruses Matrix protein M1 family. Matrix protein 1 plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.
Keywords
Influenzavirus A; Influenza A virus; Influenza A virus H5N1 M1; H5N1 M1; IAV H5N1 M1
Citations
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