Recombinant IAV H2N2 (A/Canada/720/2005) Hemagglutinin (a.a. 13-340) [His]

Product Overview

HA1 (H2N2) (A/Canada/720/2005) (AAY28987, 13 a.a. - 340 a.a.) partial recombinant protein with His tag expressed in 293 cells.

Nature

Recombinant

Tag/Conjugate

His

Format

Liquid

Concentration

1 μg/μL

Buffer

In PBS

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

H2N2 is a subtype of the type influenzavirus A. H2N2 has mutated into various strains including the Asian flu strain (now extinct in the wild), H3N2, and various strains found in birds. It is also suspected of causing a human pandemic in 1889. The geographic spreading of the 1889 Russian flu have been studied and published.

Antigen Description

Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. Hemagglutinin binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. It plays a major role in the determination of host range restriction and virulence and is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.

Keywords

Influenzavirus A; Influenza A virus; Influenza A virus H2N2; H2N2; IAV H2N2