Hygromycin B is an aminoglycoside antibiotic produced by Streptomyces hygroscopicus that inhibits protein synthesis in both prokaryotic and eukaryotic cells. It functions by interfering with ribosomal translocation, leading to rapid inhibition of translation and cell death. Hygromycin B is widely used as a selective agent in molecular biology and cell culture to maintain cells or organisms harboring hygromycin resistance genes. Its defined chemical structure, potent antimicrobial activity, and stability make it valuable for genetic engineering, molecular cloning, and antibiotic resistance studies.
Keywords
Hygromycin B; Aminoglycoside antibiotic; Protein synthesis inhibitor
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