General Notes
This product (Catalog No. DMAB-CBAS106) is a mouse-derived monoclonal antibody raised against human SYT1. This antibody exhibits cross-reactivity with Human SYT1 from rat. It has been affinity purified by Protein A. SYT1 (Synaptotagmin 1) is a gene that encodes a protein involved in the regulation of synaptic vesicle exocytosis, which is the process of releasing neurotransmitters from neurons into the synaptic cleft. The SYT1 protein acts as a calcium sensor, triggering the fusion of synaptic vesicles with the presynaptic membrane when calcium levels rise, thereby enabling the release of neurotransmitters. Mutations or alterations in the SYT1 gene have been associated with various neurological and neurodevelopmental disorders. Studies have shown that disruptions in SYT1 function can lead to impaired neurotransmitter release, synaptic dysfunction, and neurological symptoms. For example, certain SYT1 mutations have been linked to forms of epilepsy, intellectual disability, and autism spectrum disorder. The specific mechanisms by which SYT1 dysfunction contributes to these diseases are still being investigated, but the role of SYT1 in regulating synaptic vesicle exocytosis and neurotransmitter release appears to be crucial for proper brain function and development.
DMAB-CBAS106 is suitable for use in ELISA(Det) application.
DMAB-CBAS106 is supplied as a liquid formulation in Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
COA
Publication 
Loading ......
