Product Overview
Recombinant human SOX2 is a single, non-glycosylated, polypeptide chain containing 208 amino acids (1-200 a.a.). It is fused to an 8 amino acid His-Tag at C-terminus.
Alternative Names
SOX2; SRY (sex determining region Y)-box 2; ANOP3; MCOPS3; transcription factor SOX-2; transcription factor SOX2; SRY-related HMG-box gene 2
Purity
> 90% as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements
Buffer
20mM Tris-HCl pH-8, 2mM DTT, 0.2M NaCl, 40% glycerol
Storage
Short term 2-8°C, long term: -20°C
Introduction
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Keywords
Sex determining region; SOX2; HMG
Citations
Publication ()
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