The lyophilized protein is stable at room temperature for up 1 month and at 4°C up to 6 months. Working aliquots stored with a carrier protein are stable for at least 12 months at -20°C to -80°C. Please avoid repeated freezethaw cycles.
Reconstitution
We recommend a quick spin followed by reconstitution in sterile filtered water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% HSA) and store in working aliquots at -20°C to -80°C.
Introduction
Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as "orphan" G protein-coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of the pubic ligaments and ripening of the cervix during birth.
Keywords
RLN2; Relaxin-2; Prorelaxin H2; RLXH2; H2-RLX
Citations
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