Product Overview
Mouse myeloma cell line, NS0-derived human Trypsin 1/PRSS1 protein, Ala16-Ser247, with a C-terminal 10-His tag.
Predicted N terminal
Ala16
Molecular Weight
Predicted Molecular Mass: 26 kDa
SDS-PAGE: 32 kDa and 36 kDa, reducing conditions
Bio-activity
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >3,000 pmol/min/μg.
Endotoxin
<1.0 EU per 1 μg of the protein by the LAL method.
Alternative Names
Serine protease 1; PRSS1; TRP1; TRY1; TRYP1; Anionic trypsin I; Anionic trypsin-I; Beta-trypsin; Cationic trypsinogen; Pretrypsinogen I; Trypsin I; Trypsin-1
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Buffer
Supplied as a 0.2 μm filtered solution in HCl and NaCl.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70°C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
Introduction
PRSS1 is the gene that codes for cationic trypsinogen (trypsin 1), a precursor to the digestive enzyme trypsin. This protein is secreted by the pancreas and activated in the small intestine to break down proteins. Mutations in the PRSS1 gene are associated with hereditary pancreatitis, a disorder characterized by recurrent episodes of pancreatitis that can lead to chronic pancreatic damage, enzyme deficiency, and an increased risk of pancreatic cancer.
Keywords
Serine protease 1; PRSS1; TRP1; TRY1; TRYP1; Anionic trypsin I; Anionic trypsin-I; Beta-trypsin; Cationic trypsinogen; Pretrypsinogen I; Trypsin I; Trypsin-1
Citations
Publication ()
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COA
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