Magic™ Rabbit Anti-Human PINK1 Monoclonal antibody, clone 351550H9

Antibody Isotype

IgG

Clone

351550H9

Species Reactivity

Human

Immunogen

PINK1 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT1041 - DMAB-CPT1042

General Notes

This product (Catalog No. DMAB-CPT1042) is a rabbit-derived monoclonal antibody raised against human PINK1. It has been affinity purified by Protein A. PINK1 is a mitochondrial serine/threonine-protein kinase that protects cells from stress-induced mitochondrial dysfunction. The precursor of PINK1 (65 kDa) is synthesized in the cytosol and is imported into the outer membrane of mitochondria. PINK1 is further transferred into the inner membrane. The full-length PINK1 can be proteolytically processed into 52-55 kDa and 45-46 kDa forms (PMID: 18221368; 25108683; 18031932). The half-life of the mature form of PINK1 is very short and it was proposed that the proteasome is involved in its degradation (PMID: 23472196). The gene of PINK1 maps to chromosome 1p36.12. Two alternatively spliced variants exist, the shorter isoform (30 kDa) produced by alternative splicing. Mutations in the PINK1 gene cause autosomal recessive early-onset Parkinson's disease.
DMAB-CPT1042 is suitable for use in CBA(Det), ELISA(Det) applications.
DMAB-CPT1042 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

PTEN-induced putative kinase protein 1; PTEN induced putative kinase 1; PARK6; EC:2.7.11.1; BRPK

Entrez Gene ID

UniProt ID