Product Overview
Full Length NR4A2 was expressed with a polyhistidine tag at the N-terminus.
Molecular Weight
68.6 kDa
Alternative Names
NR4A2; Nuclear receptor subfamily 4 group A member 2; NURR1; TINUR
Purity
>90% as determined by SDS-PAGE.
Format
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
Tris-based buffer,50% glycerol
Storage
Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Introduction
NR4A2 (Nuclear Receptor Subfamily 4 Group A Member 2) is a Protein Coding gene. Diseases associated with NR4A2 include parkinson disease, late-onset and extraosseous chondrosarcoma. Among its related pathways are Gene Expression and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is NR1H3. This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Keywords
NR4A2; Nuclear receptor subfamily 4 group A member 2; NURR1; TINUR; HZF 3; HZF3
Citations
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