Magic™ Rabbit Anti-Human NEDD9 Monoclonal antibody, clone 351421B3

Antibody Isotype

IgG

Clone

351421B3

Species Reactivity

Human

Immunogen

NEDD9 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT989 - DMAB-CPT990
Cytometric Bead Array: 0.625-80 ng/mL

General Notes

This product (Catalog No. DMAB-CPT990) is a rabbit-derived monoclonal antibody raised against human NEDD9. It has been affinity purified by Protein A. NEDD9, also known as CASL, HEF1, contains an N-terminal Src homology (SH) 3 domain and an adjacent domain composed of multiple SH2-binding motifs(PMID: 8668148). Cell cycle-regulated processing produces four isoforms: p115, p105, p65, and p55. Isoform p115 arises from p105 phosphorylation and appears later in the cell cycle. Isoform p55 arises from p105 as a result of cleavage at a caspase cleavage-related site and it appears specifically at mitosis. p105 and p115 are predominantly cytoplasmic and associated with focal adhesions, whereas p55associates with the mitotic spindle.
DMAB-CPT990 is suitable for use in Cytometric Bead Array (0.625-80 ng/mL) application.
DMAB-CPT990 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

CAS L; CAS2; CASL; CASS2; dJ49G10.2; dJ761I2.1; Enhancer of filamentation 1; HEF1; NEDD 9; NEDD9; p105; neural precursor cell expressed, developmentally down-regulated 9

Entrez Gene ID

UniProt ID