General Notes
This product (Catalog No. DMAB-CPT750) is a rabbit-derived monoclonal antibody raised against human NEDD4. It has been affinity purified by Protein A. NEDD4 and similar proteins discovered subsequently became a family of HECT ligases, comprising 9 human proteins including NEDD4, NEDD4-2 (NEDD4L), ITCH, SMURF1, SMURF2, WWP1, WWP2, NEDL1 and NEDL2. NEDD4 is a highly evolutionarily conserved protein from yeast to man, and was initially cloned as a highly expressed gene in the early embryonic brain. NEDD4 is frequently overexpressed in many different types of cancer, and decreased levels of NEDD4 can also be associated with cancer. It can be a potential therapeutic target for the treatment of human cancer. The human NEDD4 gene is located on chromosome 15q21.3 and comprises 30 exons (HGNC:7727) shown to encode a ~120 KDa protein. Otherwise there is a 75 kDa isoform in addition to full length NEDD4.
DMAB-CPT750 is suitable for use in Sandwich ELISA (0.313-20 ng/mL) application.
DMAB-CPT750 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
Alternative Names
KIAA0093; HECT-type E3 ubiquitin transferase NEDD4; EC:2.3.2.26; E3 ubiquitin-protein ligase NEDD4; Cell proliferation-inducing gene 53 protein; neural precursor cell expressed, developmentally down-regulated 4
COA
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