General Notes
This product (Catalog No. DMAB-CBAS084) is a mouse-derived monoclonal antibody raised against human MMP2. It has been affinity purified by Protein A. MMP2 is an enzyme that plays a crucial role in extracellular matrix remodeling and tissue repair. It functions by cleaving type IV collagen, a major component of basement membranes, and is involved in various physiological processes such as menstruation, angiogenesis, and bone remodeling. MMP2 has been implicated in several pathological conditions, including chronic kidney disease (CKD) and multicentric osteolysis, nodulosis, and arthropathy (MONA).In CKD, MMP2 exhibits a dual role. During early stages, it promotes extracellular matrix production and accelerates kidney fibrosis. However, in advanced stages, MMP2 activity decreases, leading to reduced extracellular matrix degradation and exacerbating fibrosis. Mutations in the MMP2 gene can cause MONA, a rare inherited bone disease characterized by progressive bone loss and joint problems. These mutations eliminate MMP2 function, disrupting the balance between bone creation and breakdown during remodeling.
DMAB-CBAS084 is suitable for use in ELISA(Cap) application.
DMAB-CBAS084 is supplied as a liquid formulation in Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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