Magic™ Rabbit Anti-Human IL17RB Monoclonal antibody, clone 341540F2

Antibody Isotype

IgG

Clone

341540F2

Species Reactivity

Human

Immunogen

Peptide

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT759 - DMAB-CPT760
Cytometric Bead Array: 0.078-2.5 ng/mL

General Notes

This product (Catalog No. DMAB-CPT760) is a rabbit-derived monoclonal antibody raised against human IL17RB. It has been affinity purified by Protein A. IL-17RB, also known as IL17RH1, belongs to the cytokine receptor family. IL-17RB possesses a unique intracellular signaling molecule called SEFIR, and is expressed similarily to fibroblast growth factor genes and IL-17R. It is reported to be expressed on iNKT cells, innate lymphoid cells (ILC), and Th2 cells. It binds IL-17B and IL-17E (IL-25) but not IL-17A or C. Its interaction with IL-25 has a higher affinity than that with IL-17B. Binding of IL-17RB and IL-25/IL-17E induces NF-kB mediated IL-8 production through interaction with TRAF6 and Act1. IL-17RB has been reported to play a role in autoimmune diseases such as rheumatoid arthritis and asthma.
DMAB-CPT760 is suitable for use in Cytometric Bead Array (0.078-2.5 ng/mL) application.
DMAB-CPT760 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

IL17RB; IL-17RB; interleukin 17 receptor B; Evi27; IL-17ER; IL17RH1; IL17br; IL-17 receptor B

Entrez Gene ID

UniProt ID