Product Overview
Biotinylated Recombinant Human Growth arrest-specific protein 6 is produced by our Mammalian expression system and the target gene encoding Ala31-Ala678 is expressed with a Avi, 6His tag at the C-terminus.
Endotoxin
Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Alternative Names
Growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand; AXLLG; GAS6
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Buffer
Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Storage
Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Introduction
Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. It also can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry.
Keywords
Growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand; AXLLG; GAS6
Citations
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COA
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