Magic™ Rabbit Anti-Human ECSIT Monoclonal antibody, clone 351334B8

Antibody Isotype

IgG

Clone

351334B8

Species Reactivity

Human

Immunogen

ECSIT fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT883 - DMAB-CPT884
Cytometric Bead Array: 3.13-100 ng/mL

General Notes

This product (Catalog No. DMAB-CPT884) is a rabbit-derived monoclonal antibody raised against human ECSIT. It has been affinity purified by Protein A. ECSIT is a cytosolic adaptor protein associated with the toll-like receptor pathway. It has a distinct N-terminal mitochondrial targeting sequence, pentatricopeptide repeat motif, and a C-terminal pleckstrin homology domain. ECSIT regulates many biological processes like embryonic development, inflammation, cardiac function, and assembly of mitochondrial complex I. In macrophages, the activation of TLRs by inflammatory signals promotes the translocation of TRAF6 to mitochondria where it engages ECSIT to stimulate the production of mitochondrial reactive oxygen species (ROS).
DMAB-CPT884 is suitable for use in Cytometric Bead Array (3.13-100 ng/mL) application.
DMAB-CPT884 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

ECSIT; ECSIT homolog (Drosophila); Protein SITPEC; SITPEC

Entrez Gene ID

UniProt ID